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Functional characterization of Vif proteins from HIV-1 infected patients with different APOBEC3G haplotypes
OBJECTIVE: The human cytidine deaminase APOBEC3G (A3G) potently restricts HIV-1 but the virus, in turn, expresses a Vif protein which degrades A3G. A natural A3G-H186R variant, common in African populations, has been associated with a more rapid AIDS disease progression, but the underlying mechanism...
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| Pubblicato in: | AIDS |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4925190/ https://ncbi.nlm.nih.gov/pubmed/27064995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000001113 |
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