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The Structural Interface between HIV-1 Vif and Human APOBEC3H

Human APOBEC3H (A3H) is a cytidine deaminase that inhibits HIV-1 replication. To evade this restriction, the HIV-1 Vif protein binds A3H and mediates its proteasomal degradation. To date, little information on the Vif-A3H interface has been available. To decipher how both proteins interact, we first...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Ooms, Marcel, Letko, Michael, Simon, Viviana
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309942/
https://ncbi.nlm.nih.gov/pubmed/28031368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02289-16
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