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The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer’s disease

BACKGROUND: Alzheimer’s disease (AD) is characterized by senile plaques, extracellular deposits composed primarily of amyloid–beta (Aβ), and neurofibrillary tangles, which are abnormal intracellular inclusions containing hyperphosphorylated tau. The amyloid cascade hypothesis posits that the deposit...

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Опубликовано в: :Mol Brain
Главные авторы: Watanabe, Kiwamu, Uemura, Kengo, Asada, Megumi, Maesako, Masato, Akiyama, Haruhiko, Shimohama, Shun, Takahashi, Ryosuke, Kinoshita, Ayae
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670528/
https://ncbi.nlm.nih.gov/pubmed/26637371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-015-0174-2
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