Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL

Relapse is the leading cause of mortality in children with acute lymphoblastic leukemia (ALL). Among chemotherapeutics, thiopurines are key drugs in the backbone of ALL combination therapy. Using whole-exome sequencing, we identified relapse-specific mutations in phosphoribosyl pyrophosphate synthet...

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Библиографические подробности
Опубликовано в: :Nat Med
Главные авторы: Li, Benshang, Li, Hui, Bai, Yun, Kirschner-Schwabe, Renate, Yang, Jun J, Chen, Yao, Lu, Gang, Tzoneva, Gannie, Ma, Xiaotu, Wu, Tongmin, Li, Wenjing, Lu, Haisong, Ding, Lixia, Liang, Huanhuan, Huang, Xiaohang, Yang, Minjun, Jin, Lei, Kang, Hui, Chen, Shuting, Du, Alicia, Shen, Shuhong, Ding, Jianping, Chen, Hongzhuan, Chen, Jing, von Stackelberg, Arend, Gu, Longjun, Zhang, Jinghui, Ferrando, Adolfo, Tang, Jingyan, Wang, Shengyue, Zhou, Bin-Bing S.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670083/
https://ncbi.nlm.nih.gov/pubmed/25962120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3840
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