Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL

Relapse is the leading cause of mortality in children with acute lymphoblastic leukemia (ALL). Among chemotherapeutics, thiopurines are key drugs in the backbone of ALL combination therapy. Using whole-exome sequencing, we identified relapse-specific mutations in phosphoribosyl pyrophosphate synthet...

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Publicado no:Nat Med
Main Authors: Li, Benshang, Li, Hui, Bai, Yun, Kirschner-Schwabe, Renate, Yang, Jun J, Chen, Yao, Lu, Gang, Tzoneva, Gannie, Ma, Xiaotu, Wu, Tongmin, Li, Wenjing, Lu, Haisong, Ding, Lixia, Liang, Huanhuan, Huang, Xiaohang, Yang, Minjun, Jin, Lei, Kang, Hui, Chen, Shuting, Du, Alicia, Shen, Shuhong, Ding, Jianping, Chen, Hongzhuan, Chen, Jing, von Stackelberg, Arend, Gu, Longjun, Zhang, Jinghui, Ferrando, Adolfo, Tang, Jingyan, Wang, Shengyue, Zhou, Bin-Bing S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670083/
https://ncbi.nlm.nih.gov/pubmed/25962120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3840
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