Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant

Growing evidence suggests the Δ133p53α isoform may function as an oncogene. It is overexpressed in many tumors, stimulates pathways involved in tumor progression, and inhibits some activities of wild-type p53, including transactivation and apoptosis. We hypothesized that Δ133p53α would have an even...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell Death Dis
Päätekijät: Slatter, T L, Hung, N, Bowie, S, Campbell, H, Rubio, C, Speidel, D, Wilson, M, Baird, M, Royds, J A, Braithwaite, A W
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2015
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669831/
https://ncbi.nlm.nih.gov/pubmed/26068791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.149
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