Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant

Growing evidence suggests the Δ133p53α isoform may function as an oncogene. It is overexpressed in many tumors, stimulates pathways involved in tumor progression, and inhibits some activities of wild-type p53, including transactivation and apoptosis. We hypothesized that Δ133p53α would have an even...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Slatter, T L, Hung, N, Bowie, S, Campbell, H, Rubio, C, Speidel, D, Wilson, M, Baird, M, Royds, J A, Braithwaite, A W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669831/
https://ncbi.nlm.nih.gov/pubmed/26068791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.149
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