Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death

Apoptosis is a key mechanism for metazoans to eliminate unwanted cells. Resistance to apoptosis is a hallmark of many cancer cells and a major roadblock to traditional chemotherapy. Recent evidence indicates that inhibition of caspase-dependent apoptosis sensitizes many cancer cells to a form of non...

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Detalles Bibliográficos
Publicado en:Cell Death Dis
Autores principales: Moriwaki, K, Bertin, J, Gough, P J, Orlowski, G M, Chan, F KM
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669795/
https://ncbi.nlm.nih.gov/pubmed/25675296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.16
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