Pharmacologic inhibition of lactate production prevents myofibroblast differentiation

Myofibroblasts are one of the primary cell types responsible for the accumulation of extracellular matrix in fibrosing diseases, and targeting myofibroblast differentiation is an important therapeutic strategy for the treatment of pulmonary fibrosis. Transforming growth factor-β (TGF-β) has been sho...

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Veröffentlicht in:Am J Physiol Lung Cell Mol Physiol
Hauptverfasser: Kottmann, Robert Matthew, Trawick, Emma, Judge, Jennifer L., Wahl, Lindsay A., Epa, Amali P., Owens, Kristina M., Thatcher, Thomas H., Phipps, Richard P., Sime, Patricia J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669339/
https://ncbi.nlm.nih.gov/pubmed/26408551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00058.2015
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