Activated human T lymphocytes inhibit TGFβ-induced fibroblast to myofibroblast differentiation via prostaglandins D(2) and E(2)

In pulmonary fibrosis (PF), fibroblasts and myofibroblasts proliferate and deposit excessive extracellular matrix in the interstitium, impairing normal lung function. Because most forms of PF have a poor prognosis and limited treatment options, PF represents an urgent unmet need for novel, effective...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Lacy, Shannon H., Epa, Amali P., Pollock, Stephen J., Woeller, Collynn F., Thatcher, Thomas H., Phipps, Richard P., Sime, Patricia J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966783/
https://ncbi.nlm.nih.gov/pubmed/29351444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00565.2016
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