Activated human T lymphocytes inhibit TGFβ-induced fibroblast to myofibroblast differentiation via prostaglandins D(2) and E(2)

In pulmonary fibrosis (PF), fibroblasts and myofibroblasts proliferate and deposit excessive extracellular matrix in the interstitium, impairing normal lung function. Because most forms of PF have a poor prognosis and limited treatment options, PF represents an urgent unmet need for novel, effective...

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Pubblicato in:Am J Physiol Lung Cell Mol Physiol
Autori principali: Lacy, Shannon H., Epa, Amali P., Pollock, Stephen J., Woeller, Collynn F., Thatcher, Thomas H., Phipps, Richard P., Sime, Patricia J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966783/
https://ncbi.nlm.nih.gov/pubmed/29351444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00565.2016
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