Pharmacologic inhibition of lactate production prevents myofibroblast differentiation

Myofibroblasts are one of the primary cell types responsible for the accumulation of extracellular matrix in fibrosing diseases, and targeting myofibroblast differentiation is an important therapeutic strategy for the treatment of pulmonary fibrosis. Transforming growth factor-β (TGF-β) has been sho...

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Udgivet i:Am J Physiol Lung Cell Mol Physiol
Main Authors: Kottmann, Robert Matthew, Trawick, Emma, Judge, Jennifer L., Wahl, Lindsay A., Epa, Amali P., Owens, Kristina M., Thatcher, Thomas H., Phipps, Richard P., Sime, Patricia J.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2015
Fag:
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669339/
https://ncbi.nlm.nih.gov/pubmed/26408551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00058.2015
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