Pharmacologic inhibition of lactate production prevents myofibroblast differentiation

Myofibroblasts are one of the primary cell types responsible for the accumulation of extracellular matrix in fibrosing diseases, and targeting myofibroblast differentiation is an important therapeutic strategy for the treatment of pulmonary fibrosis. Transforming growth factor-β (TGF-β) has been sho...

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Bibliographic Details
Published in:Am J Physiol Lung Cell Mol Physiol
Main Authors: Kottmann, Robert Matthew, Trawick, Emma, Judge, Jennifer L., Wahl, Lindsay A., Epa, Amali P., Owens, Kristina M., Thatcher, Thomas H., Phipps, Richard P., Sime, Patricia J.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669339/
https://ncbi.nlm.nih.gov/pubmed/26408551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00058.2015
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