Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models

PURPOSE: Preclinical studies show that Inhibition of aurora kinases in melanoma tumors induces senescence and reduces tumor growth, but does not cause tumor regression. Additional preclinical models are needed to identify agents that will synergize with aurora kinase inhibitors to induce tumor regre...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Liu, Yan, Hawkins, Oriana E., Vilgelm, Anna E., Pawlikowski, Jeffrey S., Ecsedy, Jeffrey A., Sosman, Jeffrey A., Kelley, Mark C., Richmond, Ann
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4668227/
https://ncbi.nlm.nih.gov/pubmed/26152738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0293
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