Multiple gastrointestinal polyps in patients treated with BRAF inhibitors

PURPOSE: BRAF inhibitors (BRAFi) extend survival in BRAF mutant melanoma but can promote the growth of Ras mutant neoplasms. This study determined if gastrointestinal polyps found in BRAFi-treated patients harbored Ras mutations. EXPERIMENTAL DESIGN: Colonic and gastric polyps were identified and re...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Amaravadi, Ravi K., Hamilton, Kathryn E., Ma, Xiaohong, Piao, Shengfu, Del Portillo, Armando, Nathanson, Katherine L., Carlino, Matteo S., Long, Georgina V., Puzanov, Igor, Xu, Xiaowei, Morrissette, Jennifer J.D., Tsai, Kenneth Y., Flaherty, Keith T., Sosman, Jeffrey A., Goodman, Grant R., McArthur, Grant A., Rustgi, Anil K., Metz, David C., Schuchter, Lynn M., Chapman, Paul B., Sepulveda, Antonia R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4668213/
https://ncbi.nlm.nih.gov/pubmed/26202952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0469
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