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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
BACKGROUND: The identification of somatic mutations in the gene encoding the serine–threonine protein kinase B-RAF (BRAF) in the majority of melanomas offers an opportunity to test oncogene-targeted therapy for this disease. METHODS: We conducted a multicenter, phase 1, dose-escalation trial of PLX4...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3724529/ https://ncbi.nlm.nih.gov/pubmed/20818844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1002011 |
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