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Biological challenges of BRAF inhibitor therapy

Activating mutations in BRAF, a constituent of the map kinase pathway, were first discovered as being most prevalent in melanoma in 2002. Only recently have potent and selective, orally available inhibitors of BRAF emerged for clinical testing and demonstrated clear evidence of tumor regression in t...

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Detalles Bibliográficos
Publicado en:Mol Oncol
Autores principales: Puzanov, Igor, Burnett, Patrick, Flaherty, Keith T.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2011
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528282/
https://ncbi.nlm.nih.gov/pubmed/21393075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2011.01.005
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