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Biological challenges of BRAF inhibitor therapy

Activating mutations in BRAF, a constituent of the map kinase pathway, were first discovered as being most prevalent in melanoma in 2002. Only recently have potent and selective, orally available inhibitors of BRAF emerged for clinical testing and demonstrated clear evidence of tumor regression in t...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Puzanov, Igor, Burnett, Patrick, Flaherty, Keith T.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528282/
https://ncbi.nlm.nih.gov/pubmed/21393075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2011.01.005
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