A Low Frequency of Losses in 11q Chromosome Is Associated with Better Outcome and Lower Rate of Genomic Mutations in Patients with Chronic Lymphocytic Leukemia

To analyze the impact of the 11q deleted (11q-) cells in CLL patients on the time to first therapy (TFT) and overall survival (OS), 2,493 patients with CLL were studied. 242 patients (9.7%) had 11q-. Fluorescence in situ hybridization (FISH) studies showed a threshold of 40% of deleted cells to be o...

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Veröffentlicht in:PLoS One
Hauptverfasser: Hernández, José Ángel, Hernández-Sánchez, María, Rodríguez-Vicente, Ana Eugenia, Grossmann, Vera, Collado, Rosa, Heras, Cecilia, Puiggros, Anna, Martín, Ana África, Puig, Noemí, Benito, Rocío, Robledo, Cristina, Delgado, Julio, González, Teresa, Queizán, José Antonio, Galende, Josefina, de la Fuente, Ignacio, Martín-Núñez, Guillermo, Alonso, José María, Abrisqueta, Pau, Luño, Elisa, Marugán, Isabel, González-Gascón, Isabel, Bosch, Francesc, Kohlmann, Alexander, González, Marcos, Espinet, Blanca, Hernández-Rivas, Jesús María
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667902/
https://ncbi.nlm.nih.gov/pubmed/26630574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143073
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