Next-generation sequencing and FISH studies reveal the appearance of gene mutations and chromosomal abnormalities in hematopoietic progenitors in chronic lymphocytic leukemia

BACKGROUND: Chronic lymphocytic leukemia (CLL) is a highly genetically heterogeneous disease. Although CLL has been traditionally considered as a mature B cell leukemia, few independent studies have shown that the genetic alterations may appear in CD34+ hematopoietic progenitors. However, the presen...

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Bibliografiske detaljer
Udgivet i:J Hematol Oncol
Main Authors: Quijada-Álamo, Miguel, Hernández-Sánchez, María, Robledo, Cristina, Hernández-Sánchez, Jesús-María, Benito, Rocío, Montaño, Adrián, Rodríguez-Vicente, Ana E., Quwaider, Dalia, Martín, Ana-África, García-Álvarez, María, Vidal-Manceñido, María Jesús, Ferrer-Garrido, Gonzalo, Delgado-Beltrán, María-Pilar, Galende, Josefina, Rodríguez, Juan-Nicolás, Martín-Núñez, Guillermo, Alonso, José-María, García de Coca, Alfonso, Queizán, José A., Sierra, Magdalena, Aguilar, Carlos, Kohlmann, Alexander, Hernández, José-Ángel, González, Marcos, Hernández-Rivas, Jesús-María
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387353/
https://ncbi.nlm.nih.gov/pubmed/28399885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-017-0450-y
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