The CRISPR/Cas9 system efficiently reverts the tumorigenic ability of BCR/ABL in vitro and in a xenograft model of chronic myeloid leukemia

CRISPR/Cas9 technology was used to abrogate p210 oncoprotein expression in the Boff-p210 cell line, a pro-B line derived from interlukin-3-dependent Baf/3, that shows IL-3-independence arising from the constitutive expression of BCR-ABL p210. Using this approach, pools of Boff-p210-edited cells and...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: García-Tuñón, Ignacio, Hernández-Sánchez, María, Ordoñez, José Luis, Alonso-Pérez, Veronica, Álamo-Quijada, Miguel, Benito, Rocio, Guerrero, Carmen, Hernández-Rivas, Jesús María, Sánchez-Martín, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432235/
https://ncbi.nlm.nih.gov/pubmed/28212528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15215
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