Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2.
BCR-ABL is a chimeric oncogene generated by translocation of sequences from the c-abl protein-tyrosine kinase gene on chromosome 9 into the BCR gene on chromosome 22. Alternative chimeric proteins, p210BCR-ABL and p190BCR-ABL, are produced that are characteristic of chronic myelogenous leukemia and...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41679/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7777499/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.12.5287 |
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