Biological significance of monoallelic and biallelic BIRC3 loss in del(11q) chronic lymphocytic leukemia progression

BIRC3 is monoallelically deleted in up to 80% of chronic lymphocytic leukemia (CLL) cases harboring del(11q). In addition, truncating mutations in the remaining allele of this gene can lead to BIRC3 biallelic inactivation, which has been shown to be a marker for reduced survival in CLL. Nevertheless...

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Pubblicato in:Blood Cancer J
Autori principali: Quijada-Álamo, Miguel, Hernández-Sánchez, María, Rodríguez-Vicente, Ana-Eugenia, Pérez-Carretero, Claudia, Rodríguez-Sánchez, Alberto, Martín-Izquierdo, Marta, Alonso-Pérez, Verónica, García-Tuñón, Ignacio, Bastida, José María, Vidal-Manceñido, María Jesús, Galende, Josefina, Aguilar, Carlos, Queizán, José Antonio, González-Gascón y Marín, Isabel, Hernández-Rivas, José-Ángel, Benito, Rocío, Ordóñez, José Luis, Hernández-Rivas, Jesús-María
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8270906/
https://ncbi.nlm.nih.gov/pubmed/34244476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-021-00520-5
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