Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions

Genomic complexity identified by chromosome banding analysis (CBA) predicts a worse clinical outcome in CLL patients treated either with standard or new treatments. Herein, we analyzed the clinical impact of complex karyotypes (CK) with or without high-risk FISH deletions (ATM and/or TP53, HR-FISH)...

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Publicat a:Oncotarget
Autors principals: Puiggros, Anna, Collado, Rosa, Calasanz, Maria José, Ortega, Margarita, Ruiz-Xivillé, Neus, Rivas-Delgado, Alfredo, Luño, Elisa, González, Teresa, Navarro, Blanca, García-Malo, MaDolores, Valiente, Alberto, Hernández, José Ángel, Ardanaz, María Teresa, Piñan, María Ángeles, Blanco, María Laura, Hernández-Sánchez, María, Batlle-López, Ana, Salgado, Rocío, Salido, Marta, Ferrer, Ana, Abrisqueta, Pau, Gimeno, Eva, Abella, Eugènia, Ferrá, Christelle, Terol, María José, Ortuño, Francisco, Costa, Dolors, Moreno, Carol, Carbonell, Félix, Bosch, Francesc, Delgado, Julio, Espinet, Blanca
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589581/
https://ncbi.nlm.nih.gov/pubmed/28903342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17350
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