Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors

Plasmepsin II (PMII) is one of the ten plasmepsins (PMs) identified in the genome of Plasmodium falciparum, the causative agent of the most severe and deadliest form of malaria. Owing to the emergence of P. falciparum strains that are resistant to current antimalarial agents such as chloroquine and...

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Bibliografiske detaljer
Udgivet i:Acta Crystallogr F Struct Biol Commun
Main Authors: Recacha, Rosario, Leitans, Janis, Akopjana, Inara, Aprupe, Lilija, Trapencieris, Peteris, Jaudzems, Kristaps, Jirgensons, Aigars, Tars, Kaspars
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2015
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666482/
https://ncbi.nlm.nih.gov/pubmed/26625296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X15022049
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