Nucleosome compaction facilitates HP1γ binding to methylated H3K9

The α, β and γ isoforms of mammalian heterochromatin protein 1 (HP1) selectively bind to methylated lysine 9 of histone H3 via their chromodomains. Although the phenotypes of HP1-knockout mice are distinct for each isoform, the molecular mechanisms underlying HP1 isoform-specific function remain elu...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Mishima, Yuichi, Jayasinghe, Chanika D., Lu, Kai, Otani, Junji, Shirakawa, Masahiro, Kawakami, Toru, Kimura, Hironobu, Hojo, Hironobu, Carlton, Peter, Tajima, Shoji, Suetake, Isao
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Gene regulation, Chromatin and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666388/
https://ncbi.nlm.nih.gov/pubmed/26319017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv841
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