Cell Cycle-Dependent Turnover of 5-Hydroxymethyl Cytosine in Mouse Embryonic Stem Cells

Hydroxymethylcytosine in the genome is reported to be an intermediate of demethylation. In the present study, we demonstrated that maintenance methyltransferase Dnmt1 scarcely catalyzed hemi-hydroxymethylated DNA and that the hemi-hydroxymethylated DNA was not selectively recognized by the SRA domai...

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Autors principals: Otani, Junji, Kimura, Hironobu, Sharif, Jafar, Endo, Takaho A., Mishima, Yuichi, Kawakami, Toru, Koseki, Haruhiko, Shirakawa, Masahiro, Suetake, Isao, Tajima, Shoji
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858372/
https://ncbi.nlm.nih.gov/pubmed/24340069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082961
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