Dual Functions of the RFTS Domain of Dnmt1 in Replication-Coupled DNA Methylation and in Protection of the Genome from Aberrant Methylation

In mammals, DNA methylation plays important roles in embryogenesis and terminal differentiation via regulation of the transcription-competent chromatin state. The methylation patterns are propagated to the next generation during replication by maintenance DNA methyltransferase, Dnmt1, in co-operatio...

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Udgivet i:PLoS One
Main Authors: Garvilles, Ronald Garingalao, Hasegawa, Takashi, Kimura, Hironobu, Sharif, Jafar, Muto, Masahiro, Koseki, Haruhiko, Takahashi, Saori, Suetake, Isao, Tajima, Shoji
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575159/
https://ncbi.nlm.nih.gov/pubmed/26383849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137509
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