The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.

Tau is a neuronal phosphoprotein whose expression is developmentally regulated. A single tau isoform is expressed in fetal human brain but six isoforms are expressed in adult brain, with the fetal isoform corresponding to the shortest of the adult isoforms. Phosphorylation of tau is also development...

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Bibliographische Detailangaben
Hauptverfasser: Goedert, M, Jakes, R, Crowther, R A, Six, J, Lübke, U, Vandermeeren, M, Cras, P, Trojanowski, J Q, Lee, V M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1993
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC46655/
https://ncbi.nlm.nih.gov/pubmed/8506352
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