AP-2 Is the Crucial Clathrin Adaptor Protein for CD4 Downmodulation by HIV-1 Nef in Infected Primary CD4(+) T Cells

HIV-1 Nef-mediated CD4 downmodulation involves various host factors. We investigated the importance of AP-1, AP-2, AP-3, V1H-ATPase, β-COP, and ACOT8 for CD4 downmodulation in HIV-1-infected short hairpin RNA (shRNA)-expressing CD4(+) T cells and characterized direct interaction with Nef by Förster...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Gondim, Marcos Vinicius, Wiltzer-Bach, Linda, Maurer, Brigitte, Banning, Carina, Arganaraz, Enrique, Schindler, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665253/
https://ncbi.nlm.nih.gov/pubmed/26423947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01838-15
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