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How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4
The Nef protein of HIV-1 downregulates the cell surface co-receptor CD4 by hijacking the clathrin adaptor complex AP-2. The structural basis for the hijacking of AP-2 by Nef is revealed by a 2.9 Å crystal structure of Nef bound to the α and σ2 subunits of AP-2. Nef binds to AP-2 via its central loop...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3901399/ https://ncbi.nlm.nih.gov/pubmed/24473078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01754 |
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