How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4

The Nef protein of HIV-1 downregulates the cell surface co-receptor CD4 by hijacking the clathrin adaptor complex AP-2. The structural basis for the hijacking of AP-2 by Nef is revealed by a 2.9 Å crystal structure of Nef bound to the α and σ2 subunits of AP-2. Nef binds to AP-2 via its central loop...

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Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Ren, Xuefeng, Park, Sang Yoon, Bonifacino, Juan S, Hurley, James H
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2014
Konular:
Biophysics and Structural Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901399/
https://ncbi.nlm.nih.gov/pubmed/24473078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01754
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