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Structural Basis for Recruitment and Activation of the AP-1 Clathrin Adaptor Complex by Arf1

AP-1 is a clathrin adaptor complex that sorts cargo between the trans-Golgi network and endosomes. AP-1 recruitment to these compartments requires Arf1-GTP. The crystal structure of the tetrameric core of AP-1 in complex with Arf1-GTP, together with biochemical analyses, shows that Arf1 activates ca...

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Hlavní autoři: Ren, Xuefeng, Farias, Ginny G., Canagarajah, Bertram J., Bonifacino, Juan S., Hurley, James H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913725/
https://ncbi.nlm.nih.gov/pubmed/23415225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.12.042
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