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Structural Basis for Recruitment and Activation of the AP-1 Clathrin Adaptor Complex by Arf1
AP-1 is a clathrin adaptor complex that sorts cargo between the trans-Golgi network and endosomes. AP-1 recruitment to these compartments requires Arf1-GTP. The crystal structure of the tetrameric core of AP-1 in complex with Arf1-GTP, together with biochemical analyses, shows that Arf1 activates ca...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3913725/ https://ncbi.nlm.nih.gov/pubmed/23415225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.12.042 |
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