Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis.

The simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) Nef proteins induce the endocytosis of CD4 and class I MHC molecules. Here we show that SIV Nef interacts with the AP-2 adaptor complex via two elements located in the N-terminal region of the Nef molecule, but o...

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Detalhes bibliográficos
Main Authors: Lock, M, Greenberg, M E, Iafrate, A J, Swigut, T, Muench, J, Kirchhoff, F, Shohdy, N, Skowronski, J
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171354/
https://ncbi.nlm.nih.gov/pubmed/10329619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.10.2722
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