Cooperative Interactions of Simian Immunodeficiency Virus Nef, AP-2, and CD3-ζ Mediate the Selective Induction of T-Cell Receptor-CD3 Endocytosis

The Nef proteins of human immunodeficiency virus and simian immunodeficiency virus (SIV) bind the AP-1 and AP-2 clathrin adaptors to downmodulate the expression of CD4 and CD28 by recruiting them to sites of AP-2 clathrin-dependent endocytosis. Additionally, SIV Nef directly binds the CD3-ζ subunit...

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Autores principales: Swigut, Tomek, Greenberg, Michael, Skowronski, Jacek
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC161955/
https://ncbi.nlm.nih.gov/pubmed/12829850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.14.8116-8126.2003
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