Cooperative Interactions of Simian Immunodeficiency Virus Nef, AP-2, and CD3-ζ Mediate the Selective Induction of T-Cell Receptor-CD3 Endocytosis

The Nef proteins of human immunodeficiency virus and simian immunodeficiency virus (SIV) bind the AP-1 and AP-2 clathrin adaptors to downmodulate the expression of CD4 and CD28 by recruiting them to sites of AP-2 clathrin-dependent endocytosis. Additionally, SIV Nef directly binds the CD3-ζ subunit...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Swigut, Tomek, Greenberg, Michael, Skowronski, Jacek
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Virus-Cell Interactions
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC161955/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12829850/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.14.8116-8126.2003
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