HIV-1 Nef Binds the DOCK2–ELMO1 Complex to Activate Rac and Inhibit Lymphocyte Chemotaxis

The infectious cycle of primate lentiviruses is intimately linked to interactions between cells of the immune system. Nef, a potent virulence factor, alters cellular environments to increase lentiviral replication in the host, yet the mechanisms underlying these effects have remained elusive. Since...

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Autori principali: Janardhan, Ajit, Swigut, Tomek, Hill, Brian, Myers, Michael P, Skowronski, Jacek
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2004
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC314466/
https://ncbi.nlm.nih.gov/pubmed/14737186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020006
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