Mechanism for down-regulation of CD28 by Nef
SIV and HIV Nef proteins disrupt T-cell receptor machinery by down-modulating cell surface expression of CD4 and expression or signaling of CD3–TCR. Nef also down-modulates class I major histocompatibility complex (MHC) surface expression. We show that SIV and HIV-1 Nefs down-modulate CD28, a major...
Spremljeno u:
| Izdano u: | EMBO J |
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| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2001
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145469/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11285224/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.7.1593 |
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