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Mechanism for down-regulation of CD28 by Nef
SIV and HIV Nef proteins disrupt T-cell receptor machinery by down-modulating cell surface expression of CD4 and expression or signaling of CD3–TCR. Nef also down-modulates class I major histocompatibility complex (MHC) surface expression. We show that SIV and HIV-1 Nefs down-modulate CD28, a major...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC145469/ https://ncbi.nlm.nih.gov/pubmed/11285224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.7.1593 |
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