Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes.

The Nef protein of primate lentiviruses down-regulates the cell surface expression of CD4 and probably MHC I by connecting these receptors with the endocytic machinery. Here, we reveal that Nef interacts with the mu chains of adaptor complexes, key components of clathrin-coated pits. For human immun...

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Hlavní autoři: Piguet, V, Chen, Y L, Mangasarian, A, Foti, M, Carpentier, J L, Trono, D
Médium: Artigo
Jazyk:Inglês
Vydáno: 1998
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170589/
https://ncbi.nlm.nih.gov/pubmed/9564030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.9.2472
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