MDA5 Is Critical to Host Defense during Infection with Murine Coronavirus

Infection with the murine coronavirus mouse hepatitis virus (MHV) activates the pattern recognition receptors melanoma differentiation-associated gene 5 (MDA5) and Toll-like receptor 7 (TLR7) to induce transcription of type I interferon. Type I interferon is crucial for control of viral replication...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Zalinger, Zachary B., Elliott, Ruth, Rose, Kristine M., Weiss, Susan R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665247/
https://ncbi.nlm.nih.gov/pubmed/26423942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01470-15
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