Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region

Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 form a heterodimer and mediate receptor interactions and viral fusion. Both E1 and E2 are targets of the neutralizing antibody (NAb) response and are candidates for the production of vaccines that generate humoral immunity. Previous studies de...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Alhammad, Yousef, Gu, Jun, Boo, Irene, Harrison, David, McCaffrey, Kathleen, Vietheer, Patricia T., Edwards, Stirling, Quinn, Charles, Coulibaly, Fásseli, Poumbourios, Pantelis, Drummer, Heidi E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665232/
https://ncbi.nlm.nih.gov/pubmed/26378182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02070-15
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