Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region

Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 form a heterodimer and mediate receptor interactions and viral fusion. Both E1 and E2 are targets of the neutralizing antibody (NAb) response and are candidates for the production of vaccines that generate humoral immunity. Previous studies de...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: Alhammad, Yousef, Gu, Jun, Boo, Irene, Harrison, David, McCaffrey, Kathleen, Vietheer, Patricia T., Edwards, Stirling, Quinn, Charles, Coulibaly, Fásseli, Poumbourios, Pantelis, Drummer, Heidi E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
Materias:
Structure and Assembly
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665232/
https://ncbi.nlm.nih.gov/pubmed/26378182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02070-15
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