An Optimized Hepatitis C Virus E2 Glycoprotein Core Adopts a Functional Homodimer That Efficiently Blocks Virus Entry

The hepatitis C virus (HCV) envelope glycoprotein E2 is the major target of broadly neutralizing antibodies in vivo and is the focus of efforts in the rational design of a universal B cell vaccine against HCV. The E2 glycoprotein exhibits a high degree of amino acid variability which localizes to th...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: McCaffrey, Kathleen, Boo, Irene, Owczarek, Catherine M., Hardy, Matthew P., Perugini, Matthew A., Fabri, Louis, Scotney, Pierre, Poumbourios, Pantelis, Drummer, Heidi E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309951/
https://ncbi.nlm.nih.gov/pubmed/28031364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01668-16
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