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A Conserved Gly(436)-Trp-Leu-Ala-Gly-Leu-Phe-Tyr Motif in Hepatitis C Virus Glycoprotein E2 Is a Determinant of CD81 Binding and Viral Entry
The hepatitis C virus (HCV) glycoproteins E1 and E2 form a heterodimer that mediates CD81 receptor binding and viral entry. In this study, we used site-directed mutagenesis to examine the functional role of a conserved G(436)WLAGLFY motif of E2. The mutants could be placed into two groups based on t...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1563787/ https://ncbi.nlm.nih.gov/pubmed/16873241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00029-06 |
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