Escape of Hepatitis C Virus from Epitope I Neutralization Increases Sensitivity of Other Neutralization Epitopes

The hepatitis C virus (HCV) E2 glycoprotein is a major target of the neutralizing antibody (nAb) response, with multiple type-specific and broadly neutralizing antibody (bnAb) epitopes identified. The 412-to-423 region can generate bnAbs that block interaction with the cell surface receptor CD81, wi...

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Publicado en:J Virol
Autores principales: Gu, Jun, Hardy, Joshua, Boo, Irene, Vietheer, Patricia, McCaffrey, Kathleen, Alhammad, Yousef, Chopra, Abha, Gaudieri, Silvana, Poumbourios, Pantelis, Coulibaly, Fasséli, Drummer, Heidi E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2018
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899191/
https://ncbi.nlm.nih.gov/pubmed/29467319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02066-17
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