Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson’s disease patients

Lewy bodies (LBs), which mainly consist of α-synuclein (α-syn), are neuropathological hallmarks of patients with Parkinson’s disease (PD). The fine structure of LBs is unknown, and LBs cannot be made artificially. Nevertheless, many studies have described fibrillisation using recombinant α-syn purif...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Araki, Katsuya, Yagi, Naoto, Ikemoto, Yuka, Yagi, Hisashi, Choong, Chi-Jing, Hayakawa, Hideki, Beck, Goichi, Sumi, Hisae, Fujimura, Harutoshi, Moriwaki, Taro, Nagai, Yoshitaka, Goto, Yuji, Mochizuki, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664933/
https://ncbi.nlm.nih.gov/pubmed/26621077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17625
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