The secondary structural difference between Lewy body and glial cytoplasmic inclusion in autopsy brain with synchrotron FTIR micro-spectroscopy

Lewy bodies (LBs) and glial cytoplasmic inclusions (GCIs) are specific aggregates found in Parkinson’s disease (PD) and multiple system atrophy (MSA), respectively. These aggregates mainly consist of α-synuclein (α-syn) and have been reported to propagate in the brain. In animal experiments, the fib...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Araki, Katsuya, Yagi, Naoto, Ikemoto, Yuka, Hayakawa, Hideki, Fujimura, Harutoshi, Moriwaki, Taro, Nagai, Yoshitaka, Murayama, Shigeo, Mochizuki, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7656264/
https://ncbi.nlm.nih.gov/pubmed/33173082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76565-6
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