Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα

Protein Kinase A (PKA) is the major receptor for the cyclic adenosine monophosphate (cAMP) secondary messenger in eukaryotes. cAMP binds to two tandem cAMP-binding domains (CBD-A and -B) within the regulatory subunit of PKA (R), unleashing the activity of the catalytic subunit (C). While CBD-A in RI...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Akimoto, Madoka, McNicholl, Eric Tyler, Ramkissoon, Avinash, Moleschi, Kody, Taylor, Susan S., Melacini, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664472/
https://ncbi.nlm.nih.gov/pubmed/26618408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002305
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