Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons

Substantial proportions of mammalian genomes comprise repetitive elements including endogenous retrotransposons. Although these play diverse roles during development, their appropriate silencing is critically important in maintaining genomic integrity in the host cells. The major mechanism for retro...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Hatanaka, Yuki, Inoue, Kimiko, Oikawa, Mami, Kamimura, Satoshi, Ogonuki, Narumi, Kodama, Eiichi N., Ohkawa, Yasuyuki, Tsukada, Yu-ichi, Ogura, Atsuo
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2015
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664303/
https://ncbi.nlm.nih.gov/pubmed/26546670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512775112
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