Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons

Substantial proportions of mammalian genomes comprise repetitive elements including endogenous retrotransposons. Although these play diverse roles during development, their appropriate silencing is critically important in maintaining genomic integrity in the host cells. The major mechanism for retro...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Hatanaka, Yuki, Inoue, Kimiko, Oikawa, Mami, Kamimura, Satoshi, Ogonuki, Narumi, Kodama, Eiichi N., Ohkawa, Yasuyuki, Tsukada, Yu-ichi, Ogura, Atsuo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664303/
https://ncbi.nlm.nih.gov/pubmed/26546670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512775112
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