The histone chaperone CAF-1 safeguards somatic cell identity

Cellular differentiation involves profound remodeling of chromatic landscapes, yet the mechanisms by which somatic cell identity is subsequently maintained remain incompletely understood. To further elucidate regulatory pathways that safeguard the somatic state, we performed two comprehensive RNAi s...

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Pubblicato in:Nature
Autori principali: Cheloufi, Sihem, Elling, Ulrich, Hopfgartner, Barbara, Jung, Youngsook L, Murn, Jernej, Ninova, Maria, Hubmann, Maria, Badeaux, Aimee I, Ang, Cheen Euong, Tenen, Danielle, Wesche, Daniel J, Abazova, Nadezhda, Hogue, Max, Tasdemir, Nilgun, Brumbaugh, Justin, Rathert, Philipp, Jude, Julian, Ferrari, Francesco, Blanco, Andres, Fellner, Michaela, Wenzel, Daniel, Zinner, Marietta, Vidal, Simon E, Bell, Oliver, Stadtfeld, Matthias, Chang, Howard Y., Almouzni, Genevieve, Lowe, Scott W, Rinn, John, Wernig, Marius, Aravin, Alexei, Shi, Yang, Park, Peter, Penninger, Josef M, Zuber, Johannes, Hochedlinger, Konrad
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866648/
https://ncbi.nlm.nih.gov/pubmed/26659182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature15749
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