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Loss of adenomatous polyposis coli gene function disrupts thymic development
Loss of the adenomatous polyposis coli (APC) protein is a common initiating event in colon cancer. Here we show that thymocyte-specific loss of APC deregulated β-catenin signaling and suppressed Notch-dependent transcription. These events promoted the proliferation of cells of the double-negative 3...
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| Publicado no: | Nat Immunol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4662936/ https://ncbi.nlm.nih.gov/pubmed/16025118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni1228 |
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